Green Tea Benefits For Bone Marrow And Fighting Amyloidosis

Good news for fans of tea, green tea benefits is able to prevent the development of harmful proteins. A compound found in green tea leaves has the potential to save the lives of patients fighting multiple myeloma and amyloidosis. According to scientists from Washington University, these patients usually suffer from medical complications and often fatal, caused by disorders of the bone marrow. This study is published in the Journal of Biological Chemistry.

Amyloidosis is the term for a variety of conditions with the accumulation of amyloid proteins in organs and tissues, where conditions have resulted in the onset of disease. At least, the human body composed of 25 proteins and mostly found in blood plasma.

Green Tea Benefits For Bone Marrow

Some types of systemic amyloidosis can attack organ-specific, but there is also a genetic disorder due to mutations in the precursor protein. Changes in secondary form caused by other diseases, thus causing excessive formation of abnormal proteins, such as multiple myeloma. Can also establishment of sustainable excessive acute phase proteins in chronic inflammation.

This research is studying how proteins fold and formed themselves, and how these processes affect some diseases. Compounds Epigallocatechine-3-gallate (EGCG), a polyphenol found in green tea leaves. 

These compounds are consider to be very beneficial for patients fighting multiple myeloma and amyloidosis, they are susceptible to conditions that are often fatal. This causes the body's antibodies become disabled and can accumulate in various organs, usually the heart and kidneys.

The team of scientists isolate simple protein chain of nine patients with bone marrow disorder that causes multiple myeloma or amyloidosis. Then tested in the laboratory to determine how the green tea benefits for bone marrow can affect protein light chain. Scientists are also studying how the compound of green tea leaves on the ground level, and clinical trials conducted in patients with Alzheimer's in Berlin and patients with Parkinson's in China.

Prof Bieschke previously examined the effects of EGCG compound in Parkinson's disease and Alzheimer's. He found that these compounds are able to prevent the development of dangerous proteins that appeared in both diseases. In patients with bone marrow, the compound EGCG change Amyloid light chain thereby preventing replication and collect it. Green tea leaves have a different internal structure, the compound ECGC pull chain proteins into various types of aggregates that are not toxic and does not form a fibril structure, as happened in organs affected by amyloidosis.

Reference

• The power of tea, Engineering team finds compound may halt molecular cause of often-fatal condition, 06 February 2017, by Washington University in St. Louis.
• Aggregation of Full Length Immunoglobulin Light Chains from AL Amyloidosis Patients Is Remodeled by Epigallocatechin-3-gallate. Journal of Biological Chemistry, 2016; jbc.M116.750323 DOI: 10.1074/jbc.M116.750323